Sickle cell disease (SCD) is a group of genetically inherited autosomal disorders that results from the production of abnormal hemoglobin called as hemoglobin S (HbS). It is a recessive condition in which an individual possesses two copies of the gene to acquire SCD. SCD is characterized by different episodes of pain, hemolytic anemia, chest pain, a bout of fever, and cough which is prevalent in Mediterranean, sub-Saharian African, Indian, Bangladeshi, and Nepali. In Nepal majority of SCD cases have been reported in Tharu people who contract malaria seven times more than other Nepalese people. The molecular basis for the synthesis of hemoglobin S (HbS) in SCD is a single base pair point mutation occurring in the beta gene of hemoglobin A where amino acid valine is substituted for glutamic acid at position 6 of beta-globin chain.

01-12

The Hospital and Healthcare Management MBA Program is structured to provide education and training in hospital and healthcare leadership, to address hospital and healthcare issues, by integrating management science and proven business methods with knowledge of hospital and healthcare sectors and industry, hospital administrative and clinical structure, medical services, health care delivery, and public health.

13-21

With growing prevalence of occupational dissatisfaction and stress in healthcare professionals in India, there is a parallel rising concern for adverse influence on the doctor’s own health, the patient’s care, and reduction in overall quality of healthcare system in the country. This study is a brief survey of personal experiences, opinions, and beliefs in a group of 350 healthcare professionals in an urban setting in India. The study aims to explore the underlying attitudes and practices in doctors working in India in the current circumstances, as opposed to global affairs. Interestingly, the results display a unique blend of gratitude and disappointments in many doctors who continue to show up to work every day as frontline warriors; saving lives and serving humanity.

22-25

Teratomas are tumors that arise from germ cells and can be present in gonads or other regions of the body and consist of tissues of all three germ cell layers. Primary teratomas, which have not spread from any gonadal organs, in the midline retroperitoneal region are particularly rare. They account for 1-11% of all retroperitoneal neoplasms. We report a case of a Midline Primary Retroperitoneal Mature Teratoma in an 11-month-old child. The characteristic imaging findings revealed a combination of different tissues in the tumor. Successful surgery was performed to excise the tumor completely, and the child is doing well. Careful clinical examination, timely imaging, and skillful surgical management are crucial to tackling the tumor.

26-31

Tuberculosis (TB) is a major public health problem worldwide. India accounts for 1/4th of the global cases. Pulmonary TB is common in males whereas genital TB is common among females, usually in the latent form. Female genital TB presents as chronic infertility resulting from unilateral or bilateral tubal block. It is an important cause of failure of assisted reproductive techniques. We have various tools to diagnose TB, but genital TB has some limitations particularly due to deep seated involvement of the fallopian tubes. Mantoux test appears to be a useful tool in such cases.The present case highlights how the diagnosis of genital TB was missed in an infertile woman in spite of using routine testing methods and Mantoux test paved the way towards the right direction; and the treatment resulted in successful outcome.

32-35

A 29-year-old full term primigravida with gestational hypertension had been planned for elective lower segment caesarean section (LSCS). She had a history of osteoarthritis of the hip joint. Intraoperatively she was managed with general anaesthesia after failed spinal anaesthesia. We encountered unanticipated difficulties with airway management while providing general anaesthesia.

36-39

Chemical burns are serious ocular emergencies that require early evaluation and immediate management since they can result in blindness. The majority of casualties are children, and these injuries take place at home, at work, while playing and can also occur as intentional crimes. Injuries from alkali happen more common and severe than those from acids. Chemical eye injuries result in severe damage to the cornea, anterior segment, limbal stem cells, and ocular surface epithelium, which can cause impaired vision partially or permanently in one or both eyes. Therefore, emergency management is the most crucial element in selecting the visual outcome.

40-44

Calligonum polygonoides L. is locally known as Phog, Phoglo etc. in western Rajasthan. It is widely distributed in arid regions of world from Saudi Arabia to desert of Rajasthan. It is to It is an important shrub for stabilization of sand dunes. Traditionally, it is used as fuel and also for treatment of heat-stroke. Several phyto-chemicals are present in the plant for example, butanolides- calligonolides A and B, various flavanoids like quercetin and their derivatives, kaempferol, steroidal compounds, tannins etc. A number of pharmacological activities such as cytotoxic, antioxidant, antibacterial, antifungal, antiviral, and antidiabetic have been reported from the plant in scientific studies carried out world over.

45-53

54-57

58-59